Projects

1. Modification of enzymes using Continuous Directed Evolution

Catalytic Cycles to Replacement (CCR) is a key parameter used to assess the longevity and efficiency of enzymes. A lower CCR indicates a shorter working life, requiring more frequent replacement through breakdown and resynthesis. In our lab, we identify enzymes with potential for improvement and apply advanced continuous directed evolution techniques, combined with machine learning, to enhance their performance. Additionally, we focus on evolving “good enough” enzymes to achieve even better functionality and efficiency.

2. Sustainable Bioconversion of Lignocellulosic Waste into High-Value Commodities through Metabolic Engineering

Our research focusses on transforming lignocellulosic waste into valuable commodities through advanced metabolic engineering. By integrating enzyme evolution, metabolic engineering, and synthetic biology, we convert forest waste into bacterial cellulose in a sustainable manner. Additionally, we harness microbes as cell factories to produce organic acids from lignocellulosic biomass.